Gastroesophageal reflux disease (gerd) is a chronic disorder of the upper gastrointestinal tract with global distribution the incidence is on the increase in different parts of the world in the last 30 to 40 years, research findings have given rise to a more robust understanding of its pathophysiology, clinical presentation, and management the current definition of gerd (the montreal. Gerd journal articles. Clinical history and questionnaires typical gerd symptoms (heartburn and acid regurgitation) are more likely than atypical symptoms to respond to treatment, emphasising the value of an accurate clinical history5 however, when compared with objective evidence of gerd defined by ph-metry or endoscopy, even an expert history by a gastroenterologist has only 70% sensitivity and 67% specificity.
gerd journal articles
Gastroesophageal reflux disease (gerd) is the most common gastrointestinal disease, and the cost of health care and lost productivity due to gerd is extremely high recently described side effects of long-term acid suppression have increased the interest in nonpharmacologic methods for alleviating gerd symptoms we aimed to examine whether gerd patients follow recommended dietary guidelines. An article on laparoscopic antireflux surgery vs esomeprazole treatment for chronic gerd was published in the may 18, 2011, issue of jama. a clinical review of barrett esophagus and risk of esophageal cancer and accompanying online video were published in the august 14, 2013, issue of jama .. The pathogenesis of gastroesophageal reflux disease (gerd) is complex and involves changes in reflux exposure, epithelial resistance, and visceral sensitivity. the gastric refluxate is a noxious material that injures the esophagus and elicits symptoms. esophageal exposure to gastric refluxate is the primary determinant of disease severity. this exposure arises via compromise of the anti-reflux.
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