They are of substantially longer duration(10-45 sec) than swallow-induced les relaxation(5-8 sec) the occurrence of tlesrs is unrelated to basal les pressure tlesrs are not always accompanied by acid reflux in normal subjects about 40-60 % of tlesrs are accompanied by acid reflux, compared with 60-70 % in patients with gerd. Transient lower esophageal sphincter relaxation gerd. Keywords: transient lower esophageal sphincter relaxation, gastroesophageal reflux, esophagus, acid, vagus nerve transient lower esophageal sphincter relaxations (tlesrs) allow belching to vent the swallowed air from the stomach( 1 – 4 ).
transient lower esophageal sphincter relaxation gerd
Obesity is associated with increased transient lower esophageal sphincter relaxation wu jc(1), mui lm, cheung cm, chan y, sung jj author information: (1)institute of digestive disease, the chinese university of hong kong, hong kong justinwu@cuhkeduhk. The predominant mechanism causing gerd is transient lower esophageal sphincter (les) relaxation, which is defined as an abrupt decrease in les pressure to the level of intragastric pressure, unrelated to swallowing and of relatively longer duration than the relaxation triggered by a swallow..
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