G masclee, in side effects of drugs annual, 2014 drugs used in the treatment of gout uricase is a hepatic enzyme that converts uric acid into allantoin, which is more easily excreted by the kidney because of its water-soluble compoundin humans, a missense and frame shift mutation during evolution resulted in an inactivated gene encoding uricase. Uric acid to allantoin drug. Achieves its therapeutic effect by catalyzing oxidation of uric acid to allantoin, thereby lowering serum uric acid levels indicated for gout in adults refractory to conventional therapy (ie, serum uric acid levels have failed to normalize and signs and symptoms are inadequately controlled with xanthine oxidase inhibitors at maximum.
uric acid to allantoin drug
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